Does anyone use their mouse in the cockpit to operate switches, knobs, levers, etc. like we did in all the earlier sims?

Mine only highlites the control, then asks me what button I'm supposed to push!?!? I cannot get the mouse to interact with anything in the sim, although the curser does highlite what would normally be clickable, along with nomenclature.

When I have my Saitek panels connected, they work most everything, as does the Alpha and Bravo yoke and throttle.
Since I don't have any of those connected right now, I would like to be able to just use the mouse as before. Ideas? Settings?